货品编号： sigma.c3144-10mg 品牌：sigma 品名：辅酶 A 钠盐 水合物 规格：10mg 产品描述： Application Coenzyme A is suitable for use in: •gylcerolipid biosynthesis in porcine adipose tissue[1] •an assay to measure the level of Alpha-methylacyl-CoA racemase (AMACR) in human blood samples using a

nanoparticle electrochemical biosensor[2] •chloramphenicol acetyltransferase (CAT) assay[3][4] •the synthesis of palmitoyl-CoA, which is required for palmitoylation and activation of proteins for regulated

membrane fusion[5]

Biochem/physiol Actions Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and

supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes.

In the presence of CoASH, organic carboxylic acids form acyl-CoA thioesters, which facilitates enzyme recognition.

The acyl-CoA formed from xenobiotic carboxylic acids can add to the compound′s toxicity, which can lead to cellular

metabolic dysfunction.[6] It is involved in the oxidation of pyruvate in the Kreb′s cycle.