货品编号： Bioss.bs-13664R 品牌： Bioss 品名：Rabbit Anti-SOCS5 antibody 规格： 100ul 产品描述： background:

The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2,

SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal

region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS

box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction.

Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced,

the various members of the SOCS family appear to inhibit signaling in different ways. During Th1 differentiation a reduction

in the association of Jak1 with the IL4 Receptor correlated with the appearance of SOCS5. SOCS5 protein was preferentially

expressed in committed Th1 cells and interacted with the cytoplasmic region of the IL4 Receptor alpha chain irrespective of

receptor tyrosine phosphorylation. This unconventional interaction of SOCS5 protein with IL4 Receptor resulted in the inhibition

of IL4-mediated signal transducer and activator of transcription-6 activation. T cells from transgenic mice constitutively expressing

SOCS5 exhibited a significant reduction of IL4-mediated Th2 development. Therefore, the induced SOCS5 protein in Th1

differentiation environment may play an important role by regulating Th1 and Th2 balance.