货品编号： Bioss.bs-9001R 品牌：Bioss 品名：Rabbit Anti-SARM1 antibody 规格：100ul 产品描述： background: SARM, also known as SAMD2, SARM1 or KIAA0524, is a 724 amino acid protein that localizes to the cytoplasm and contains

one TIR domain and two sterile alpha motif (SAM) domains. Expressed predominately in liver and kidney and present at lower

levels in placenta, SARM interacts with TICAM-1 and, via this interaction, blocks the transcriptional activation activity of TICAM-1

and functions as a negative regulator of Toll-like receptor signaling. Additionally, SARM is thought to be involved in innate

immune responses and may also play a role in the negative regulation of NFⅹB activation. SARM exists as two alternatively

spliced isoforms that are encoded by a gene which maps to human chromosome 17.

Function: Involved in innate immnune response. Acts as a negative regulator of TICAM1/TRIF-dependent Toll-like receptor signaling by

inhibiting induction of TLR3- and TLR4-dependent genes. Specifically blocks TICAM1/TRIF-dependent transcription-factor activation

and gene induction, without affecting the MYD88-dependent pathway or non-TLR signaling. Negative regulator of NF-kappa-B and

IRF activation.