货品编号： Sigma.P1530-25MG 品牌：Sigma 品名：Polyinosinic–polycytidylic acid sodium salt TLR ligand tested (Sigma) TLR ligand tested 规格：25MG 产品描述： Biochem/physiol Actions
Transfection of Poly (I:C) into NIT-1 cells has been used as a model of intracellular dsRNA-induced β cell apoptosis.
Eighteen hours post transfection, 45% of the cells were apoptotic with an increase in NF-kB, p50/p65 nuclear
translocation, and cleavage of caspases 3 and 8, as well as transcriptional induction of caspase 12, Fas, IL-15, and
the TNF receptor-associated ligand (TRAIL). It has been suggested that Poly(I:C) is one of the most appropriate
generators of stable mature dendritic cells (DC). These mature DC might generate in vivo effective immune responses
after injection due to their ability to secrete bioactive IL-12 after CD40 ligation. Poly (I:C) was used as a potent adjuvant
to enhance the specific anti-tumor immune responses against a peptide-based vaccine.
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