货品编号： 博奥森.bs-13396R 品牌：博奥森 品名：谷胱甘肽过氧化酶2抗体 规格：100ul

产品描述：

background: Glutathione peroxidase (GPx) enzymes are generally selenium-containing tetrameric glycoproteins that help

prevent lipid peroxidation of cell membranes. GPx enzymes reduce lipid hydroperoxides to alcohols, and reduce

free hydrogen peroxide to water. GPx members are among the few proteins known in higher vertebrates to

contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by the nonsense

(stop) codon TGA. There are eight GPx homologs (GPx-1–8). GPx-1 plays an important role in the antioxidant

defense of the vascular wall and neural cells in response to oxidative stress. GPx-2 is the major isoform in the

lungs and its basal or inducible expression is dependent on Nrf2. GPx-3 is under regulation by hypoxic stress

and the expression and deficiency of GPx-3 is associated with cardiovascular disease and stroke. GPx-5 is

selenium-independent; it is bound to the acrosome of sperm, where it may protect sperm from premature

acrosome reaction in the epididymis.