货品编号： Thermo.PA5-20343 品牌：Thermo 品名：PD-L1 Polyclonal Antibody 规格：100ug 储存条件： Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C

产品描述： Product Specific Information A suggested positive control is Raji cell lysate.

PA5-20343 can be used with blocking peptide PEP-0463.

Background/Target Information

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides

bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T

cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1

can bind two different but related ligands, PDL-1 and PDL-2. PDL-1 is a B7-related protein that inhibits cell-mediated

immune responses by reducing the secretion of IL-2 and IL-10 from memory T cells. This suggests that PDL-1 may be

useful in reducing allogenic CD4+ memory T-cell responses to endothelial cells, thereby reducing the likelihood of host

immune responses to allografts. At least two isoforms of PDL-1 are known to exist; this antibody is specific to the larger

isoform. PDL-1 antibody has no cross-reactivity to PDL-2.