货品编号： thermo.MA1-19602 品牌：thermo 品名：CD63 Monoclonal Antibody (MEM-259), FITC 规格：100T 储存条件： 4° C, store in dark, DO NOT FREEZE!

产品描述：

Background/Target Information CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes,

lysosomes and secretory vesicles of various cell types. CD63 is also present in the plasma membrane, usually following cell

activation. Hence, CD63 has become a widely used basophil activation marker. In mast cells, however, CD63 exposition does

not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase

trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used

for predicting the prognosis in earlier stages of carcinomas. CD63 is expressed on activated platelets, and is a lysosomal membrane

glycoprotein that is translocated to plasma membrane after platelet activation. CD63 is also present in monocytes and macrophages

and is weakly expressed on granulocytes, B, and T cells. CD63 is identical to the melanoma-associated antigen which is ME491 and

to the platelet antigen PTLGP40. Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.