货品编号： 博奥森.bs-3336R 品牌：博奥森 品名：磷酸化蛋白激酶R抗体 规格：100ul 储存条件：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room

temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in

sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品描述：

background: PKR is an interferon-inducible serine/threonine specific protein kinase. It is widely expressed in eukaryotic

organisms and activated by double stranded RNA. Activation of PKR by dsRNAs leads to autophosphorylation

at multiple sites. Phosphorylation of Thr446 and Thr451 in the PKR activation loop is required in vivo and in

vitro for high level kinase activity. PKR phosphorylates its natural substrate, the alpha subunit of eukaryotic

protein synthesis initiation factor 2 (EIF2 alpha), leading to the inhibition of protein synthesis. PKR is also

involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory

cytokines, and also activates IKK and NFKB, thereby suppressing apoptosis. Recently, it has been reported that

PKR also phosphorylates human p53 on serine 392. PKR might play a role in ER stress-induced apoptosis and

in Alzheimer's disease. Alzheimer cases show prominent PKR activation in association with neuritic plaques and

pyramidal neurons in the hippocampus and neocortex.