货品编号： 博奥森.bs-20189R 品牌：博奥森 品名：线粒体钙离子单向转运蛋白MCU抗体 规格：100ul 储存条件：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at

room temperature for at least one month and for greater than a year when kept at -20°C. When

reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two

weeks at 2-4 °C.

产品描述：

background: This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein

interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.

Function: Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial

calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium

signals and activation of cell death pathways. Activity is regulated by MICU1 and MICU2 that stimulate and inhibit

MCU activity, respectively. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating

mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes.