货品编号： SANTA CRUZ.sc-376842 品牌：SANTA CRUZ 品名：anti-TTK 规格：200 µg/ml

产品描述：

Progression of cells through the cell cycle is regulated by variations in the levels and activities of a series of protein kinases

as well as by oscillation in the levels of their regulatory subunits (i.e., cyclins). The full length sequence for a unique protein

kinase of human origin, designated TTK, was cloned by screening a T cell expression library with anti-phosphotyrosine

antibodies. Similarly, the mouse homolog of TTK was isolated from an embryonal carcinoma (EC) cell line by expression

cloning. TTK/Esk are novel members of the serine-threonine/tyrosine family of protein kinases and are expressed in a broad

range of proliferating human cells and tissues. TTK-Esk expression is reduced or absent in resting cells and in cells with a low

proliferative index. When cells are induced to enter the cell cycle, levels of TTK mRNA, protein and kinase activity increase at

the G1 to S phase of the cell cycle and peak in the G2 to M phase, suggesting that TTK/Esk may function as cell cycle regulatory

components.

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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