货品编号： 博奥森.bs-1049R 品牌：博奥森 品名：Rabbit Anti-CHRNA7 antibody 规格：100ul 储存条件：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature

for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS

or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

产品描述：

background: The Nicotinic Acetylcholine Receptors are members of a superfamily of ligand gated ion channels that mediate fast signal

transmission at synapses. These receptors are thought to be hetero pentamers composed of homologous subunits. The

proposed structure for each subunit is a conserved N terminal extracellular domain followed by three conserved transmembrane

domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C terminal extracellular region.

The Nicotinic Acetylcholine Receptor alpha 7 forms a homo oligomeric channel, displays marked permeability to calcium ions and

is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha bungarotoxin. Once this receptor

binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion

conducting channel across the plasma membrane.