货品编号： apexbio.c4653 品牌：apexbio 品名：cerulenin脂肪酸合成酶（FAS）抑制剂 规格：5mg

产品描述：

Cerulenin is a fatty acid synthase (FAS) inhibitor. Fatty acids are key aliphatic acids for energy production and storage, which are synthesized by a series of

decarboxylative Claisen condensation reactions from acetyl-CoA and malonyl-CoA. In vitro: In a previous study, it was found that the inhibition of fatty acid synthesis at the physiologically regulated

step of carboxylation of acetyl-CoA to malonyl-CoA was not cytotoxic to breast cancer cells. FAS inhibitor of

cerulenin ould induce a rapid increase in intracellular malonyl-CoA to several fold, whereas 5-(tetradecyloxy)-2-furoic

acid reduced intracellular malonyl-CoA by 60%. Simultaneous exposure of breast cancer cells to 5-(tetradecyloxy)-

2-furoic acid and an FAS inhibitor of cerulenin led to significantly reduced cytotoxicity and apoptosis [1]. In vivo: To investigate the physiological effects of in-vivo inhibition of fatty acid synthesis on global lipid metabolism,

a previous study administered cerulenin or C75 to mice. Profound weight loss following treatment was observed.

Weight loss occurred dose-dependently and persisted for a duration. Moreoer, all treated mice recovered their lost

body weight after the effect of the drug dissipated. The treatments of both cerulenin and C75 were well tolerated

without obvious toxicity [2]. Clinical trial: So far, no clinical study has been conducted.