货品编号： thermo.pa5-80231 品牌：thermo 品名：WNT7A Polyclonal Antibody 规格：100UL 储存条件： -20°C

产品描述：

Product Specific Information The synthetic peptide sequence is 226-256aa, YVLKDKYNEAVHVEPVRASRNKRPTFLKIKK

Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.

Background/Target Information Wnt proteins constitute a family of secreted glyocoproteins that activate signal transduction pathways to mediate tissue

homeostasis, cell fate, cell proliferation, and self-renewal. The canonical signaling pathway is initiated upon Wnt binding

to a Frizzled family receptor and an LRP5/LRP6 coreceptor, which leads to activation of the beta-catenin cascade. Non-

canonical Wnt signals are activated by binding to a Frizzled family receptor and ROR2 coreceptor. Extensive research

has shown that deregulation of these pathways or its components can lead to cancer. Human Wnt-1 is encoded as a 370

amino acid precursor that, upon secretion, is cleaved into a 343 amino acid (42 kDa) mature form. At the amino acid level,

mature human Wnt-1 is approximately 99% identical to mature mouse Wnt-1. Depending on the tissue, Wnt-1 can activate

the canonical and non-canonical signaling pathways. Studies have demonstrated its involvement in a variety of functions,

including embryonic development and carcinogenesis. Wnt-1 signaling can also induce the phosphorylation and subsequent

degradation of c-Myb.