货品编号： Thermo.11-0388-42 品牌：Thermo 品名：CD38 Monoclonal Antibody (HB7), FITC, eBioscience™ 规格：100 tests

产品描述：

Product Specific Information Description: The HB7 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II

transmembrane protein. CD38 is an ectoenzyme which catalyses NAD into nicotinic acid adenine dinucleotide

phosphate (NAADP) and cyclic ADP-ribose (cADPR), both of which are secondary messengers. Expression of CD38

is bimodal during B cell development, modulating from high in immature cells to low in intermediate ones and back to

high on mature B cells. Additionally CD38 is found in a variety of tissues and other hematopoietic cells (e.g. T cells, NK

cells and monocytes) and can be used to phenotype leukemias and monitor HIV-1 progression. The CD34+CD38-

population of hematopoietic stems cells is thought to define the most pluripotent cells (e.g. blast colony forming cells).

In addition to surface expression, CD38 has recently been found in the nucleus where it may play a role in monitoring

calcium levels.

Applications Reported: This HB7 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This HB7 antibody has been pre-titrated and tested by flow cytometric analysis of normal human

peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that

will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from

10^5 to 10^8 cells/test.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.