产品描述： background: The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia

motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by

RefSeq, Jan 2012]

Function: Dyneins are microtubule-associated motor protein complexes which are composed of several heavy, light, and

intermediate chains. Dynein heavy chains (DHCs) are responsible for force production and ATPase activity and

contain a highly conserved catalytic domain with 4 P-loop consensus motifs involved in nucleotide binding. Two

major classes of dyneins, axonemal and cytoplasmic, have been identified. Axonemal dyneins, found in flagella

and cilia, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets.

DNAH8 is an outer arm axonemal DHC.