产品描述： background: This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin

and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and

cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer

of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are

related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion

of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic

polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy,

oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc.