货品编号： 博奥森.bs-23549R-50ul 品牌：博奥森 品名：Rabbit Anti-Neutrophil Elastase antibody 规格：50ul

产品描述： background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have

six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins

within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix

following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and

inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades

the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella,

Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital

neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and

proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are

packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].