货品编号： Biolegend329706 品牌：Biolegend 品名：PE anti-human CD274 (B7-H1, PD-L1) 规格：100 tests

产品描述： Description

CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1).

This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to

microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and

IFN-γ productionin an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit

T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274

may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B

cells, antigen-presenting cells, and nonhematopoietic cells.