货品编号： Excell ER006-96 品牌：Excell 品名：Rat TNF-α ELISA Kit 规格：96T

产品描述： Tumor necrosis factor alpha (TNF-α), also known as cachectin; and tumor necrosis factor beta (TNF-α), also known

as lymphotoxin, are two closely related proteins (approximately 34% amino acid sequence identity) that bind to the

same cell surface receptors and show many common biological functions. TNF-α and -β play a critical role in normal

host resistance to infection and to the growth of malignant tumors, serving as immunostimulants and as mediators of

the inflammatory response. Over-production of TNFs, however, has been implicated as playing a role in a number of

pathological conditions, including cachexia, septic shock, and autoimmune disorders. TNF-α is produced by activated

macrophages and other cell types including T and B cells, NK cells, LAK cells, astrocytes, endothelial cells, smooth

muscle cells and some tumor cells. Rat TNF-α cDNA encodes a 235 amino acid (aa) residue type II membrane protein.