货品编号: Bioss bs-6982R-50ul 品牌:Bioss 品名:Rabbit Anti-Neutrophil Elastase antibody 规格:50ul
产品描述: background: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin.
Humans have six elastase genes which encode the structurally similar proteins. The product of this
gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well
as proteins of the extracellular matrix following the protein's release from activated neutrophils. The
enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV
and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA)
of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia.
Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN).
This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3
genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are
packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009].
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