货品编号： biolegend.506915 品牌：biolegend 品名：APC anti-mouse IL-17A 规格：25ug

产品描述： Description

IL-17, also known as CTLA-8, is a T cell-expressed pleiotropic cytokine that exhibits a high degree of

homology to a protein encoded by the ORF13 gene of herpes virus Saimiri. IL-17 is produced by Th

cells (Th17) that are distinct from the traditional Th1- and Th2-cell subsets. IL-23 plays an important

role in triggering IL-17 production. Both recombinant and natural IL-17 have been shown to exist as

disulfide linked homodimers. IL-17 exhibits multiple biological activities on a variety of cells including:

the induction of IL-6 and IL-8 production in fibroblasts, activation of NF-κB, and costimulation of T cell

proliferation. IL-17 is an essential inflammatory mediator in the development of autoimmune diseases.

Neutralization of IL-17 with monoclonal antibody is able to ameliorate the disease course.