产品描述： Endosidin 2 (ES2) is a cell-permeable benzylidene-benzohydrazide that binds to the exocyst component of

the 70 kDa (EXO70) subunit of the exocyst complex (Kd = 253 μM, EXO70A1).1 ES2 binding inhibits exocytosis

and endosomal recycling in plant and mammalian cells. ES2 disrupts protein trafficking between the endosome

and plasma membrane, which enhances trafficking to the vacuole for degradation. It also inhibits recycling of

endocytosed transferrin to the plasma membrane in HeLa cells and can target multiple isoforms of mammalian

EXO70, resulting in misregulation of exocytosis.