货品编号： 博奥森.bs-7694R 品牌：博奥森 品名：钠氯离子转运蛋白抗体 规格：100ul

产品描述：

background: Na-K-Cl cotransporters (NKCC) are channel proteins that aid in the transcellular movement of chloride across both

secretory and absorptive epithelia. NKCC1 is expressed in muscle cells, neurons, and red blood cells. In the

basolateral membrane of secretory epithelia, NKCC1 mediates active chloride secretion. The gene encoding human

NKCC1 maps to chromosome 5q23.3. In mice, disruption of the NKCC1 gene leads to deafness and impaired balance.

NKCC2 is specifically expressed in the kidney where it mediates active reabsorption of sodium chloride in the thick

ascending limb of the loop of Henle. NKCC2 is sensitive to the clinically important diuretics furosemide and bumetanide.

The gene encoding human NKCC2 maps to chromosome 15q15-q21 and mutations in this gene lead to Bartter’s

syndrome, an inherited hypokalaemic alkalosis. NCCT is a thiazide-sensitive Na-Cl cotransporter that is primarily

expressed in the distal convoluted tubule of the kidney where it accounts for a significant fraction of net renal sodium

reabsorption. The gene for human NCCT map to chromosome 16q13. Mutations in the gene encoding NCCT cause

Gitelman’s syndrome, a subset of Bartter’s syndrome.