产品描述：

background: Predominantly localized to the nucleolus, BOP1 (Block of proliferation 1 protein) is a 746 amino acid highly

conserved non-ribosomal protein that is involved in ribosome biogenesis. Truncation of the amino terminus

of BOP1 leads to cell growth arrest in the G1 phase and specific inhibition of 28S and 5.8S rRNA synthesis,

as well as a deficit in the cytosolic 60S ribosomal subunit. This suggests that BOP1 is involved in the

formation of mature rRNAs and in the biogenesis of the 60S ribosomal subunit. BOP1 physically interacts

with pescadillo (a protein involved in cell proliferation) and enables efficient incorporation of pescadillo into

the nucleolar preribosomal complexes, thereby affecting rRNA maturation and the cell cycle. The BOP1-

pescadillo complex is also necessary for biogenesis of 60S ribosomal subunits. Deregulation of BOP1 may

lead to colorectal tumorigenesis.