产品描述：

background: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is

expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen

and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal

for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates

T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding

different isoforms.[provided by RefSeq, May 2011].