货品编号： thermo.17-0862-82 品牌：thermo 品名：CD86 (B7-2) Monoclonal Antibody (GL1), APC, eBioscience™ 规格：100ug

产品描述：

Description: The GL1 monoclonal antibody reacts with mouse CD86, an ~80 kDa surface receptor also known as B7-2.

CD86 and CD80 are members of the B7 family of costimulatory molecules. CD86 is expressed at low level on B cells,

macrophages, and dendritic cells and is upregulated on B cells through a variety of surface stimuli including the BCR

complex, CD40 and some cytokine receptors. CD86 is also expressed by activated mouse T cells and thioglycolate-

elicited peritoneal cells. In addition to CD80 (B7-1), CD86 is a counter-receptor for the T cell surface molecules CD28

and CD152 (CTLA-4). This interaction plays a critical role in T-B crosstalk, T cell costimulation, autoantibody production

and Th2-mediated Ig production. The kinetics of upregulation of CD86 upon stimulation, supports its major contribution

during the primary phase of an immune response.