货品编号： bioss.bs-1465R 品牌：bioss 品名：Rabbit Anti-GRB2 antibody 规格：100ul

产品描述：

background: Growth factor receptor bound protein 2 (GRB2), also known as Ash protein, is a 24 kDa protein that contains a

central Src homology (SH2) domain flanked by two SH3 domains. GRB2 is believed to be a regulatory subunit

of signaling molecules whose activity is modulated by receptor binding. GRB2 associates with activated (tyrosine

phosphorylated) EGFR and PDGFR via its SH2 domain as well as IRS1, SHC, and LNK through SH2 and SH3

domains. The SH3 domain binds to SOS, a guanine nucleotide exchange factor for Ras proteins. Endocytosis of

activated EGFR requires the interaction of GRB2 with the GTP binding protein dynamin, a factor essential to the

formation of endocytotic vesicle. It is ubiquitously expressed and several isoforms are produced by alternative

splicing. On SDS PAGE, GRB2 has an apparent molecular weight of 28 kDa.