货品编号： bioss.bs-10562r 品牌：bioss 品名：Rabbit Anti-JNK1+JNK2 antibody 规格：100ul

产品描述：

background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for

multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation,

differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets

specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The

activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced

apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom

c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key

role in T cell proliferation, apoptosis and differentiation. Five alternatively spliced transcript variants encoding distinct

isoforms have been reported. [provided by RefSeq, Jun 2013]