产品描述：

background: B7-H4 protein is expressed on the surface of a variety of immune cells and functions as a negative regulator

of T cell responses. While B7-H4 mRNA is widely distributed in mouse and human peripheral tissues, cell

surface expression of B7-H4 protein is limited and shows an inducible pattern on hematopoietic cells. Putative

receptor of B7-H4 can be upregulated on activated T cells. By arresting cell cycle, B7-H4 ligation of T cells has

a profound inhibitory effect on the growth, cytokine secretion, and development of cytotoxicity. Administration

of B7-H4Ig into mice impairs antigen-specific T cell responses whereas blockade of endogenous B7-H4 by

specific monoclonal antibody promotes T cell responses. B7-H4 thus may participate in negative regulation of

cell-mediated immunity in peripheral tissues.