Sigma.I5879-250mg IBMX 250mg Sigma-Aldrich


货品编号: Sigma.I5879-250mg 品牌:Sigma 品名:IBMX 规格:250mg

产品描述: Biochem/physiol Actions Non-specific inhibitor of cAMP and cGMP phosphodiesterases. The increase in cAMP level as a result of phosphodiesterase

inhibition by IBMX activates PKA leading to decreased proliferation, increased differentiation, and induction of apoptosis. IBMX

inhibits phenylephrine-induced release of 5-hydroxytryptamine from neuroendocrine epithelial cells of the airway mucosa

(IC50: 1.3 μM). Also serves as an adenosine receptor antagonist. Shown to inhibit ion channels in the neuromuscular junction,

GH3 cells, and vascular smooth muscle cells. Induces calcium release from intracellular stores in sensory neurons.

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