货品编号： bioss.bs-0349R 品牌：bioss 品名：Histone H3/HIST3H3 (Nuclear Loading Control ) 组蛋白H3抗体 规格：10ul

产品描述： Modulation of the chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of

four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. The N-terminal tail of core histones undergoes

different posttranslational modifications including acetylation, phosphorylation and methylation. These modifications occur in response to

cell signal stimuli and have a direct effect on gene expression. In most species, the histone H2B is primarily acetylated at lysines 5, 12, 15

and 20. Histone H3 is primarily acetylated at lysines 9, 14, 18 and 23. Acetylation at lysine 9 appears to have a dominant role in histone

deposition and chromatin assembly in some organisms. Phosphorylation at Ser10 of histone H3 is tightly correlated with chromosome

condensation during both mitosis and meiosis.

Function: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries

which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal

stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome

remodeling. H3 is deposited into chromatin exclusively through a DNA replication-coupled pathway that can be associated with either DNA

duplication or DNA repair synthesis during meiotic homologous recombination.