产品描述： The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart,

skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung.

TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate

mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-

triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress

macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases,

such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

Function: Receptor for bile acid. Bile acid-binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP

production. May be involved in the suppression of macrophage functions by bile acids.