产品描述： Biochem/physiol Actions An iron chelator used often in the studies of cell proliferation and apoptosis. Has been shown to have anti-proliferative

effects on vascular smooth muscle cells in vitro and in vivo and to arrest cells in the G1 phase. Also reported to induce

p53. Induces apoptosis in HL-60 cells by chelating iron. After 48 hrs treatment with 1μM deferoxamine, DNA fragmentation

was apparent. Cells treated with 0.1 μM deferoxamine for as little as 24 hours were committed to apoptosis; by 48 hrs

nuclear collapse was observed. In some studies it has been shown to have antioxidant properties and to protect cells

against H2O2-induced damage.

Deferoxamine is used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). Deferoxamine stabilizes

HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of

deferoxamine inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic

activity.