产品描述： This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with

another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK

proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and

associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Function: Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic

plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to

inhibitory synapses in hippocampal neurons. May reduce the amplitude of ACCN3 acid-evoked currents by retaining the

channel intracellularly. May regulate the intracellular trafficking of ADR1B.