货品编号：bioss.bs-1134r

品牌：bioss

品名：Rabbit Anti-RUNX2 antibody

规格：50ul

产品描述：

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain.

This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and

regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a

subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial

dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as

alternate splicing. [provided by RefSeq, Jul 2008].

Function: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and

both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and

promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein,

alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters (By similarity). Inhibits MYST4-dependent transcriptional activation. [SUBUNIT]

Interaction with SATB2 results in enhanced DNA binding and transactivation by these transcription factors (By similarity). Heterodimer of

an alpha and a beta subunit. Interacts with HIVEP3 (By similarity). The alpha subunit binds DNA as a monomer and through the Runt

domain. DNA-binding is increased by heterodimerization. Interacts with XRCC6 (Ku70) and XRCC5 (Ku80). Interacts with MYST3 and MYST4.