货品编号： bioss.bs-4593R

品牌： bioss

品名： Anti-MMP9

规格： 20ul/支

产品描述：

All cells within tissues are surrounded by an extracellular matrix (ECM) giving the tissues shape and structure. The ECM is

constantly being remodeled and constant communication is maintained between cells through this matrix. Secreted proteins,

termed matrix metalloproteinases (MMPs), are involved in the modulation of cell matrix interactions. MMPs are Zn(2+) binding

endopeptidases that degrade various components of the ECM. MMPs are enzymes implicated in normal and pathologic tissue

remodeling processes, wound healing, angiogenesis, and tumor invasion. These enzymes are very potent when active, and are

associated with extracellular space inhibitors called TIMPs (tissue inhibitors of matrix metalloproteinases). TIMPs have been

shown to block tumor cell invasion suggesting that they act as metastasis suppressor genes.

Function:

May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone

osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter

fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide.