品牌： bioss

品名： Rabbit Anti-GAPDH antibody

规格： 100ul/支

产品描述：

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis.

It catalyzes an important energy-yielding step in carbohydrate metabolism, thereversible oxidative phosphorylation of

glyceraldehyde-3-phosphatein the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD).

Recent evidence suggests that it also is involved in a number of cellular processes such as membrane fusion,

phosphotransferase activity, DNA replication and repair, and nuclear RNA export (1). GAPDH has also been implicated in

playing a role in different pathologies such as cancer progression, apoptosis, and neuronal diseases such as Alzheimer’s

and Huntington’s disease (2). GAPDH is constitutively expressed at high levels in almost all tissues and cell lines making it

ideal for use as a loading control marker in immunoblots.

Function:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and

nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and

apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear

target proteins such as SIRT1, HDAC2 and PRKDC. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in

glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-

D-glyceroyl phosphate.