品牌： 博奥森

品名： Rabbit Anti-Cathelicidin antibody

规格： 100ul

产品描述：

Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. Along with the

family of proteins known as defensins, cathelicidins participate in the first line of defense by preventing local infection and

systemic invasion of microbes. FALL-39 precursor (FALL-39 peptide antibiotic, cationic anti-microbial protein, CAMP, CAP-18,

HSD26) is a cathelicidin anti-microbial protein that contains the antibacterial peptide LL-37 (amino acids 134-170). In contrast to

the defensins, which are cysteine-rich peptides that fold in ∫-pleated sheets, LL-37 is a cysteine-free peptide that can adopt an

amphipathic å-helical conformation. LL-37 binds to bacterial lipopolysaccharides (LPS) and is a potent chemotactic factor for

recruiting mast cells to sites of inflammation. LL-37 is present in inflammatory skin diseases that include psoriasis, sub-acute

lupus erthematosus, dermatitis and nickel contact hypersensitivity. It is not found in normal skin epidermis. The secreted protein

is expressed primarily in bone marrow, testis and neutrophils. The mouse and rat ortholog, CRAMP (cathelin-related antimicrobial

peptide), is also part of the cathelicidin family of host defense peptides. These include precursors of potent antimicrobial peptides

that direct antimicrobial activity against various microbial pathogens and also activate mesenchymal cells during wound repair.

CRAMP is expressed in testis, spleen, stomach and intestine.