货品编号： bioss.bsm-33033M

品牌： bioss

品名： Mouse Anti-GAPDH-Loading Control antibody

规格： 100ul

产品描述：

Loading Control

Glyceraldehyde 3 phosphate dehydrogenase (GAPDH) is well known as one of the key enzymes involved in glycolysis.

As well as functioning as a glycolytic enzyme in cytoplasm, recent evidence suggests that mammalian GAPDH is also

involved in a great number of intracellular proceses such as membrane fusion, microtubule bundling, phosphotransferase

activity, nuclear RNA export, DNA replication, and DNA repair. During the last decade a lot of data appeared concerning

the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age

related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is constitutively

expressed in almost all tissues at high levels. There are however some physiological factors such as hypoxia and diabetes

that increase GAPDH expression in certain cell types. GAPDH molecule is composed of four 36kDa subunits.

Function:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and

nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and

apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target

proteins such as SIRT1, HDAC2 and PRKDC. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that

catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.