品牌： bioss

品名： Mouse Anti-TGF beta 1 antibody

规格： 100ul

产品描述：

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional

peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells

have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein

is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form

composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed

of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may

also form composed of a TGFB1 homodimer. The mature peptide may also form composed of a TGFB1 homodimer. The

mature peptide may also form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with

other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-

Engelmann disease.

Function:

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize

TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important

role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and

differentiation in committed osteoblasts.

Subunit:

Homodimer; disulfide-linked, or heterodimer with TGFB2. Secreted and stored as a biologically inactive form in the extracellular

matrix in a 290 kDa complex (large latent TGF-beta1 complex) containing the TGFB1 homodimer, the latency-associated peptide

(LAP), and the latent TGFB1 binding protein-1 (LTBP1). The complex without LTBP1 is known as the'small latent TGF-beta1

complex'. Dissociation of the TGFB1 from LAP is required for growth factor activation and biological activity. Release of the large

latent TGF-beta1 complex