货品编号： APExBIO. A3634
品牌： APExBIO
品名： MPTP hydrochloride
规格： 100mg
产品描述：
IC50Value:53uM（inhibitedthenerve-evokedtwitchesofphrenicnerve-hemidiaphragmpreparationsfromICRmice）.
MPTPHCl(Sigma-Chem.)inducedreductionintheDOPACHVA/dopamine(DA)ratioandincreaseinstriatalascorbate(AS)oxidationinrats.
invitro:MPTPinhibitedthenerve-evokedtwitchesofphrenicnerve-hemidiaphragmpreparationsfromICRmice(20 30g).
PP50uM,butnotPA50uMorTP50uM,potentiatedtheinhibitoryeffectofMPTP.PP100uMitselfhadaninhibitoryaction
ontwitchamplitude.TheIC50valuesfortwitchinhibitionbyMPTP,TCandPPwere53,0.7and123uM,respectively.
PretreatmentwithPP50uMreducedtheIC50valuesofMPTPandTCto18and0.3uM,respectively[2].invivo:MPTP
wasexaminedin12squirrelmonkeys(2mgevery2hrfor4doses)andhumanaddictsself-administeringvaryingdoseswithvaryingdosagepatterns.
Inotherexperiments,6squirrelmonkeys(0.6-1.0kg)receivedMPTP(2mgevery2hrfor4doses).Someanimalswere
pretreatedwithpargyline.Thesewerekilled1or12hrafterthelastMPTPdosewhiletheotherswerekilledupto72hrafterthatlasedose.
BrainconcentrationsofMPGP/MPPweredeterminedbyGC/MSonaregionalbasis[3].Clinicaltrial:TreatmentofLevodopaInduced
DyskinesiainPatientsWithParkinson'sDisease.Phase
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