APExBIO. A3634 MPTP hydrochloride 100mgAPEXBIO-耗材-金山科研平台 Thermo Fisher官网Nunc、QSP、Nalgene、Invitrogen、Gibco耗材试剂授权一级代理

APExBIO. A3634 MPTP hydrochloride 100mgAPEXBIO

货品编号： APExBIO. A3634

品牌： APExBIO

品名： MPTP hydrochloride

规格： 100mg

产品描述：

IC50Value:53uM（inhibitedthenerve-evokedtwitchesofphrenicnerve-hemidiaphragmpreparationsfromICRmice）.

MPTPHCl(Sigma-Chem.)inducedreductionintheDOPACHVA/dopamine(DA)ratioandincreaseinstriatalascorbate(AS)oxidationinrats.

invitro:MPTPinhibitedthenerve-evokedtwitchesofphrenicnerve-hemidiaphragmpreparationsfromICRmice(20 30g).

PP50uM,butnotPA50uMorTP50uM,potentiatedtheinhibitoryeffectofMPTP.PP100uMitselfhadaninhibitoryaction

ontwitchamplitude.TheIC50valuesfortwitchinhibitionbyMPTP,TCandPPwere53,0.7and123uM,respectively.

PretreatmentwithPP50uMreducedtheIC50valuesofMPTPandTCto18and0.3uM,respectively[2].invivo:MPTP

wasexaminedin12squirrelmonkeys(2mgevery2hrfor4doses)andhumanaddictsself-administeringvaryingdoseswithvaryingdosagepatterns.

Inotherexperiments,6squirrelmonkeys(0.6-1.0kg)receivedMPTP(2mgevery2hrfor4doses).Someanimalswere

pretreatedwithpargyline.Thesewerekilled1or12hrafterthelastMPTPdosewhiletheotherswerekilledupto72hrafterthatlasedose.

BrainconcentrationsofMPGP/MPPweredeterminedbyGC/MSonaregionalbasis[3].Clinicaltrial:TreatmentofLevodopaInduced

DyskinesiainPatientsWithParkinson'sDisease.Phase

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