品牌： Bioss

品名： 受体活性修饰蛋白2抗体

规格： 100ul

产品描述：

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins,

called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with

an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like

receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as

either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which

members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an

adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin

receptor to the cell surface.

Function:

RAMP2 (Receptor activity-modifying protein 2) transports the calcitonin gene-related peptide type 1 receptor (CALCRL)

to the plasma membrane. RAMP2 acts as a receptor for adrenomedullin (AM) together with CALCRL. Co-expression of

Receptor activity-modifying protein 2 (RAMP2) with the calcitonin-receptor-like-receptor (CRLR) results in the production

of a functional adrenomedullin (ADM) receptor. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-

like receptor. RAMP2 is a heterodimer of CALCRL and RAMP2. RAMP2 is strongly expressed in lung, breast, immune system

and fetal tissues. RAMP2 belongs to the RAMP family.