品牌： Abclonal

品名： [KO Validated] TRAF2 Rabbit pAb

规格： 50UL

产品描述：

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins

associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly

interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated

activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-

apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this

protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition

of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the

degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been

found for this gene, but the biological validity of only one transcript has been determined.