品牌： bioss

品名： Mouse Anti-PTEN antibody

规格： 50ul

产品描述：

Potential tumor suppressor. Acts as a phosphoinositide3-phosphatase by regulating PtdIns (3,4,5)P3 levels. Involved in

regulation of the AKT1 signaling pathway. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation.

The PTEN/MMAC1 discovers the first to have the suppress of the phosphoric acid enzyme activity cancer gene currently.

The gene of PTEN locates the chromosome10q23 area, sending forth sex tumor and a few households cancers with the

variety to suffer from the comprehensive disease easilyrelevant.The activity that passes to repress the Akt regulates the

cell period, the cell ground rule decease and glues to connect.This text discussed PTEN structure, function and its

correlationses, the PTEN is in tumor repress function mechanism.

Function:

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-

phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring

from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and

inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P >

Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB

signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival.

The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated

focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a

role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration

during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative

regulator of insulin signaling and glucose