品牌： bioss

品名： Rabbit Anti-RUNX2 antibody

规格： 20ul

产品描述：

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt

DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and

acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can

bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this

gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants

that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.