货品编号： Biolegend.126403

品牌：Biolegend

品名：PE anti-mouse FOXP3

规格：25 ug

产品描述：

FOXP3 is a 47kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is

proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface

markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to

induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked

autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression

of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central

regulator of T cell activity. In human, unlike in mouse, two isoforms of FOXP3 have been reported: one (FOXP3)

corresponding to the canonical full-length sequence; the other (FOXP3 δ2) lacking exon 2. The 150D monoclonal

antibody reacts with human, mouse and rat FOXP3. The 150D antibody recognizes FOXP3 epitope encoded by exon 2.