apexbio.B6803 Rottlerin,PKC抑制剂 50mgAPEXBIO


货品编号: apexbio.B6803

品牌: apexbio

品名: Rottlerin,PKC抑制剂

规格: 50mg

产品描述:

RottlerinisaspecificPKCinhibitor,withIC50valuesforPKCδof3-6μM,PKCα,β,γof30-42μM,PKCε,η,ζof80-100μM. Rottlerin(20μM,2/6/24hours)dramaticallydecreasesthecyclinD-1mRNAlevelsinatime-dependentmannerandexhibitscellproliferationinHMVEC. InBalbCnudemice,rottlerin(20mg,gavage5daysperweek,oncedaily,for6weeks)inhibitsAsPC-1pancreatictumorgrowthwithnotoxicity.

Rottlerininhibitstumorcellproliferation,andinducesapoptosisthroughactivationofcaspase-3andcleavageofpoly(ADP-ribose)polymerase(PARP)

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