货品编号： Apexbio.B1421 品牌：Apexbio 品名：Forskolin10mM (in 1mL DMSO) 规格：10mM (in 1mL DMSO)

产品描述： Forskolin is a cell-permeable activator of adenylyl cyclase [1]. Adenylate cyclase is an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to

3',5'-cyclic AMP (cAMP) and pyrophosphate.

Forskolin is a cell-permeable activator of adenylyl cyclase. In rat cerebral cortical membranes, forskolin

reversibly and rapidly activated adenylate cyclase with EC50 value of 5-10 μM. GTP and GDP increased

the responses to forskolin. In rat cerebral cortical slices, forskolin rapidly increased cAMP by 35-fold with

IC50 values of 25 μM [1]. Forskolin inhibited the inactivation of adenylate cyclases induced by N-ethylmaleimide

with Kd values of 7.6 and 6.3 μM for the platelet and brain adenylate cyclases, respectively. Also, forskolin protected

adenylate cyclases against thermal inactivation. Forskolin activated the platelet adenylate cyclase with IC50 and Kd

values of 3-10 μM and 9-11 μM, respectively [2]. In pig epidermal cells, forskolin activated epidermal adenylate cyclase

with Ka value of 2-3×10-5 M and induced cAMP accumulations, which then inhibited mitotic in a dose-dependent way [3].