货品编号： apexbio.B8214

品牌： apexbio

品名： Dihydrotestosterone(DHT)

规格： 25mg

产品描述：

Dihydrotestosterone is an endogenous androgen sex steroid and hormone and a potent agonist of the androgen receptor .

In AR-positive bladder cancer UMUC3 and TCC-SUP cells, dihydrotestosterone (DHT) increases the expression of EGFR

and ERBB2 both in mRNA and in protein levels. In AR-positive cell，DHT additionally upregulates the levels of phosphorylation

of EGFR (pEGFR) and its downstream proteins AKT (pAKT) and ERK1/2 (pERK), induced by EGF treatment.

DHT-treated SOD1-G93A mice demonstrate ameliorated muscle atrophy and increased body weight, which is associated with

stronger grip-strength. DHT treatment increases the expression of insulin-like growth factor-1 in muscle, which can exert

myotrophic as well as neurotrophic effects through retrograde transport. DHT treatment attenuates neuromuscular junction

denervation, and axonal and motoneuron loss. DHT-treated SOD1-G93A mice demonstrates improvement in motor behavior

as assessed by rota-rod and gait analyses, and an increased lifespan.