货品编号： Bioss.bs-2210R

品牌：Bioss

品名：Anti-phospho-p38 MAPK (Thr180 + Tyr182)磷酸化丝裂原活化蛋白激酶p38抗体

规格：100ul

产品类型 磷酸化抗体 研究领域 肿瘤细胞生物神经生物学信号转导细胞凋亡转录调节因子激酶和磷酸酶 抗体来源 Rabbit 克隆类型 Polyclonal 交叉反应 Human,Mouse,Rat,Chicken,Dog,Pig,Horse,Rabbit, 产品应用 WB=1:500-2000ELISA=1:500-1000IHC-P=1:100-500Flow-Cyt=1μg /testICC=1:100（石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 41kDa 细胞定位 细胞核细胞浆 性状 Liquid 浓度 1mg/ml 免疫原 KLH conjugated Synthesised phosphopeptide derived from human p38 MAPK around the phosphorylation site of

Thr180/Tyr182:EM(p-T)G(p-Y)VA 亚型 IgG 纯化方法 affinity purified by Protein A 储存液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. PubMed PubMed 产品介绍

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple

biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription

regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The

activation requires its phosphorylation by MAP kinase kinases(MKKs), or its autophosphorylation triggered by the interaction of

MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX,

cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and

cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding

distinct isoforms have been reported.